MERGE combines genomic and protein model features in classifiers for coding, splicing, non-coding and non-SNV variants. The ensemble is trained on labelled benchmark data and evaluated using chromosome-held-out splits. AlphaGenome is evaluated independently and is excluded from MERGE training. For splicing and non-coding variants, an optional fixed average combines MERGE with a label-free AlphaGenome percentile. View the benchmark results.
Disclaimer
This tool is provided for basic academic research purposes only and must not be used for commercial purposes. Results are for reference only and do not constitute clinical diagnostic or medical advice. Users assume all responsibility for any use of the outputs.